FIGURE 1.

The rotarod of mice. The latency time of MPTP-treated mice was significantly reduced compared to that of controls. After RAGE siRNA administration in MPTP + RAGE-siRNA group, the motor deficits of mice partly improved compared with that of MPTP + RAGE-NC mice. There was no statistical difference of latency time between control group and RAGE-NC group (mean ± SEM, n = 10, ***p < 0.001, compared with control; ^^^p < 0.001, compared with RAGE-NC group; #p < 0.05, compared with MPTP + RAGE-NC).