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. 2020 Apr 29;14:353. doi: 10.3389/fnins.2020.00353

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Copyright © 2020 Wang, Sun, Niu, Zhang, Wang, Zhou and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dopaminergic neurons staining and estimation of the total number of TH neurons in substantia nigra in six groups. MPTP administration resulted in severe nigrastriatal lesions with a marked loss of TH neurons (MPTP group vs. control). Interestingly, RAGE-siRNA treatment partly increased the survival of TH neurons (MPTP + siRNA group vs. MPTP + RNA-NC group). RAGE-NC treatment alone did not produce any effect on the dopaminergic neuronal survival ratio compared to the control group (RAGE-NC group vs. control). The quantification of TH neurons and TH protein levels in SN were lined with these changes (A,B) (mean ± SEM, n = 5 ***p < 0.001, compared with control; ^^p < 0.001, compared with RAGE-NC group; #p < 0.05, compared with MPTP + RAGE-NC group).