FIGURE 6.

Neuroinflammation induced by RAGE activation was involved in the phosphorylation of IκB and p38. COX2 expression was increased after MPTP injection, accompanied by the elevated level of phosphorylation of IκB and p38. This effect was partly inhibited by treatment with RAGE siRNA. In RAGE-NC, COX2, p-IκB, and p-p38 expressions were not significantly changed compared to control group (mean ± SEM, n = 5, ***p < 0.001 or **p < 0.01 or *p < 0.05, compared with control; ^^^p < 0.001 or ^^p < 0.01, compared with RAGE-NC group; ##p < 0.01 or #p < 0.05, compared with MPTP + RAGE NC group).