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. 2020 Apr 29;8:334. doi: 10.3389/fbioe.2020.00334

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Copyright © 2020 Fan, Kim, Bai, Diergaarde and Park.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global APA events distinct for ER+ and ER-. (A) Heatmaps showing the genes with 3′US (top panel) or 3′UL (bottom panel) in ER+ samples (left column) or ER- samples (right column), ranked by the total number of APA events. (B,C) Overlap of the recurring (>20% in samples) 3′US and 3′UL genes in ER+ and ER-, respectively. (D,E) The number of APA genes (3′US in line and 3′UL in red bar) in the tumor–normal sample pairs in ER+ and ER-, respectively, ordered as in (A).