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. 2020 Mar 20;7(9):1903718. doi: 10.1002/advs.201903718

Figure 6.

Figure 6

Tumor spheroid formation in several types of cancer cells in Matrigel, collagen I, and designer peptide hydrogels.[ 142 , 170 , 223 ] A) SMMC7721 cells. B) MDA‐MB‐231S stem‐like cancer cells (reproduced with permission, copyright 2015, Dove Press); In Matrigel, both SMMC7721 cells and MDA‐MB‐231S stem‐like cancer cells form regular tumor spheroids when cultured for 3 d or 5 d (left panels). In collagen I, both SMMC7721 cells and MDA‐MB‐231S stem‐like cancer cells cannot form regular tumor spheroid growth pattern, but grow in a stretched cell shapes (middle panels); In RADA16‐I peptide hydrogel, except of MDA‐MB‐231 cells, both SMMC7721 cells and MDA‐MB‐231S stem‐like cells form regular tumor spheroid growth pattern (right panels). C) A546 lung cancer cells; when seeded on different EFK8 hydrogels, tumor spheroidal colony growth pattern is formed in 1.25 mg mL−1 EFK8 peptide hydrogel, 5.0 mg mL−1 EFK8 peptide hydrogel, and 1.25 mg mL−1 EFK8‐SWNT hybrid hydrogel (adapted with permission.[ 196 ] Copyright 2018, Elsevier Ltd).