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Enzyme activity of IDH1/2 wildtype and IDH1/2 mutant. IDH1/2 catalyzes the oxidative decarboxylation of isocitrate to produce α‐KG, using NADP+ as cofactor and producing NADPH and CO2 in the forward reaction. IDH1/2 mutations confer a gain‐of‐function activity that catalyzes the conversion of α‐KG into the oncometabolite R2HG in a NADPH‐dependent manner.
