Table 1.
Comparison of molecular subtypes established by WHO in 2016
| IDH‐wildtype glioblastoma | IDH‐mutant glioblastoma | |
|---|---|---|
| Synonym | Primary glioblastoma | Secondary GBM |
| Mean age at diagnosis | 56–61 | 32–48 |
| Proportion of cases | 10% | 90% |
| Precursor lesion | Nonexistent; develops de novo |
Diffuse astrocytoma Anaplastic astrocytoma |
|
Median overall survival Surgery + radio/chemotherapy |
15 months | 31 months |
| Location | Supratentorial | Preferentially frontal |
| Necrosis | 90% | 50% |
| Main genetic aberrations | TERT promoter mutations, EGFR amplification, deletion of PTEN | IDH, TP53, ATRX mutations; methylation of MGMT promoter |
| Transcriptional profiles a) | Neural, proneural, mesenchymal, classical | Proneural |