Table 3.
Risk of Development Incident All-Cause Dementia Based on Level of Depressive Symptoms at Baseline.
| Short-Term Follow-Upa |
Model 2: Long-Term Follow-Upb |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dementia cases/total, N |
66/1219 |
66/696 |
||||||||||
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Age at baseline | 1.13 | 1.08-1.18 | <.001 | 1.09 | 1.05-1.13 | <.001 | 1.13 | 1.08-1.20 | <.001 | 1.14 | 1.08-1.20 | <.001 |
| Sex, female | 1.06 | 0.63-1.78 | .816 | 1.14 | 0.68-1.9 | .619 | 0.96 | 0.56-1.65 | .897 | 0.97 | 0.56-1.70 | .928 |
| Race, white | 1.01 | 0.58-1.75 | .966 | 1.74 | 0.97-3.01 | .061 | 0.63 | 0.37-1.07 | .092 | 0.88 | 0.50-1.55 | .669 |
| Education | 0.96 | 0.90-1.03 | .336 | 1.08 | 1.01-1.15 | .025 | 0.99 | 0.92-1.07 | .839 | 1.04 | 0.96-1.11 | .240 |
| Medical comorbidity | 0.92 | 0.73-1.15 | .464 | 0.98 | 0.78-1.22 | .874 | 0.89 | 0.71-1.13 | .369 | 0.90 | 0.716-1.15 | .422 |
| GDS | 1.09 | 0.99-1.20 | .070 | 1.06 | 0.961-1.17 | .234 | 1.13 | 1.01-1.26 | .028 | 1.11 | 1.01-1.22 | .043 |
| BIMC | 1.60 | 1.47-1.75 | <.001 | 1.30 | 1.15-1.46 | <.001 | ||||||
Abbreviations: BIMC, blessed information memory concentration; CI, confidence interval; GDS, Geriatric Depression Scale; HR, hazard ratio.
a
Model 1: Including patients with a diagnosis of dementia before 3 years of follow-up.
b
Model 2: Including patients with a diagnosis of dementia after 3 years of follow-up.