Table 3:

Association between Baseline Gum symptoms and Changes in Cognitive Function, Estimated from Mixed-Effects Models

	Global cognition						Episodic memory						Executive function						Working memory
	Model 1 A		Model 2 B		Model 3 C		Model 1 A		Model 2 B		Model 3 C		Model 1 A		Model 2 B		Model 3 C		Model 1 A		Model 2 B		Model 3 C
	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value	Estimate (SE)	P value
Intercept	−0.002 (0.02)	0.920	0.06 (0.05)	0.186	−0.29 (0.11)	0.001	−0.01 (0.02)	0.594	−0.04 (0.06)	0.544	−0.47 (0.15)	0.001	−0.04 (0.03)	0.163	0.08 (0.06)	0.188	−0.32 (0.15)	0.036	0.007 (0.03)	0.796	0.23 (0.06)	< 0.001	0.002 (0.15)	0.991
Time	−0.04 (0.01)	< 0.001	−0.04 (0.01)	< 0.001	−0.04 (0.01)	< 0.001	−0.003 (0.01)	0.764	−0.0006 (0.01)	0.952	−0.0006 (0.01)	0.955	−0.01 (0.01)	0.312	−0.01 (0.01)	0.319	−0.01 (0.01)	0.319	−0.05 (0.01)	< 0.001	−0.05 (0.01)	< 0.001	−0.05 (0.01)	< 0.001
Gum symptoms	0.07 (0.04)	0.082	0.04 (0.03)	0.165	0.04 (0.03)	0.159	0.10 (0.05)	0.036	0.07 (0.04)	0.118	0.07 (0.04)	0.115	0.11 (0.05)	0.040	0.02 (0.04)	0.623	0.02 (0.04)	0.574	0.05 (0.05)	0.293	0.05 (0.04)	0.282	0.04 (0.04)	0.329
Gum symptoms × Time	−0.003 (0.01)	0.834	−0.004 (0.01)	0.762	−0.004 (0.01)	0.763	−0.02 (0.02)	0.344	−0.03 (0.02)	0.265	−0.03 (0.02)	0.267	0.01 (0.02)	0.596	0.01 (0.02)	0.622	0.01 (0.02)	0.622	−0.02 (0.02)	0.309	−0.02 (0.02)	0.318	−0.02 (0.02)	0.322
Teeth symptoms	−0.05 (0.03)	0.107	−0.06 (0.02)	0.0006	−0.06 (0.02)	0.014	−0.05 (0.03)	0.111	−0.08 (0.03)	0.007	−0.07 (0.03)	0.011	−0.03 (0.04)	0.502	−0.02 (0.03)	0.482	−0.01 (0.03)	0.646	−0.02 (0.04)	0.656	−0.03 (0.03)	0.365	−0.02 (0.03)	0.490

^AModel 1: test of main effect of gum symptoms at baseline with adjustment for time, and gum symptoms × time

^BModel 2: Model 1 + sociodemographic characteristics

^CModel 3: Model 2 + health-related characteristics