Table 4.
Table summarizing changes of the CP in tumors, schizophrenia and chronic stress
| Category | Disorder | Choroidal epithelial cells | Immune cells | Transporters | Others |
|---|---|---|---|---|---|
| Tumors | CP papilloma |
↑ c-Myc expression in CP epithelium [287] |
↑ CD3+ T-lymphocytes, predominantly CD4+ T-helper and CD68+ macrophages [287] |
Expression of S-100, cytokeratin, vimentin and TTR |
|
|
Villous hypertrophy and diffuse enlargement of the CP [278] |
|||||
|
↑ Expression of AQP1 [280] |
↑ CP surface [282] |
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|
↑ TWIST1 expression [284] |
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| CP carcinoma |
↑ Ki67 proliferative indices [275] |
||||
|
↑ Myc expression [286] |
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|
Hypermethylation in the promoter region of AK1, PER2, PLSCR4 [279] |
|||||
| CP cyst |
↑ Water-filled vesicles number [283] |
||||
| Primary CP tumors |
Expression of cytokeratin AE1/AE3, E-cadherin, N-cadherin, β-catenin, GFAP |
||||
| Schizophrenia |
↑ Expression of genes related to immune function and inflammation associated with the disease status [296] |
↑ CP volume [297] |
|||
| Chorionic Stress |
↓ 5HT2C, glucocorticoid receptor, cilia genes IFT88 expression ↑ 5HT2A, BDNF, TNFα, IL-1β expression [298] |
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