Figure 5.

Percent of recovered total knee I¹³¹-rhPRG4 across time points at 10 min (day 0), days 1, 3, 6, 13, and 20 in 18 porcine following intra-articular I¹³¹-rhPRG4 delivered 5 days after ACL transection. (A) Comparison of total femoral and tibial cartilage and (B) total medial and lateral cartilage. Initially I¹³¹-rhPRG4 localized more to the medial joint compartment and tibial cartilage surfaces. Toward the end of the concentration-time profiles studied at Day 20, the lateral joint compartment and femoral cartilage retained a greater relative percentage of recoverable I¹³¹-rhPRG4. Error bars are mean SE; N =3 at each sampling time.