Table 3.
Serogroup-specific Case Fatality Rate by Case Characteristics, Clinical Manifestation, and Symptoms at Disease Onset Among Invasive Meningococcal Disease Cases, the Netherlands, January 2015 to June 2018
| W | B | Y | C | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CFR | n | CFR | n | CFR | n | CFR | n | CFR | n | P Valuea | |
| Age | .216 | ||||||||||
| <10 y | 11.1 | 2/18 | 3.8 | 4/104 | 0.0 | 0/1 | 0.0 | 0/3 | 4.8 | 6/126 | |
| 10–19 y | 24.1 | 7/29 | 3.8 | 2/52 | 28.6 | 2/7 | 0.0 | 0/2 | 12.2 | 11/90 | |
| 20–64 y | 17.3 | 14/81 | 4.2 | 3/72 | 7.7 | 1/13 | 0.0 | 0/10 | 10.2 | 18/176 | |
| ≥65 y | 13.8 | 9/65 | 2.9 | 1/34 | 2.7 | 1/37 | 90.0 | 1/10 | 8.2 | 12/146 | |
| Genderb | .964 | ||||||||||
| Males | 16.4 | 11/67 | 5.0 | 6/121 | 11.5 | 3/26 | 0.0 | 0/12 | 8.8 | 20/226 | |
| Females | 16.5 | 21/127 | 2.8 | 4/142 | 3.1 | 1/32 | 7.7 | 1/12 | 8.6 | 27/314 | |
| Comorbidities | .163 | ||||||||||
| No | 18.0 | 22/122 | 3.7 | 6/163 | 6.5 | 2/31 | 0.0 | 0/16 | 9.0 | 30/332 | |
| Yes, immunocompromised | 21.1 | 4/19 | 33.3 | 3/9 | 0.0 | 0/8 | 0.0 | 0/1 | 19.4 | 7/36 | |
| Yes, other | 13.0 | 3/23 | 0.0 | 0/17 | 12.5 | 1/8 | 0.0 | 0/2 | 8.0 | 4/50 | |
| Clinical manifestations | <.001 | ||||||||||
| Septicemia without meningitis | 27.1 | 23/85 | 9.5 | 6/63 | 10.5 | 2/19 | 14.3 | 1/7 | 18.4 | 32/174 | |
| Septicemia and meningitis | 36.4 | 4/11 | 8.0 | 2/25 | 28.6 | 2/7 | 0.0 | 0/1 | 18.2 | 8/44 | |
| Meningitis without septicemia | 3.1 | 1/32 | 1.4 | 2/142 | 0.0 | 0/12 | 0.0 | 0/8 | 1.5 | 3/194 | |
| Other | 6.2 | 4/65 | 0.0 | 0/30 | 0.0 | 0/19 | 0.0 | 0/9 | 3.3 | 4/123 | |
| Symptomsc: diarrhea | <.001 | ||||||||||
| No | 10.6 | 12/113 | 6.2 | 7/112 | 3.2 | 1/31 | 0.0 | 0/10 | 7.5 | 20/266 | |
| Yes, with IMD-specific symptomsd | 40.0 | 2/5 | 0.0 | 0/5 | NaN | 0/0 | 0.0 | 0/1 | 18.2 | 2/11 | |
| Yes, without IMD-specific symptomsd | 52.4 | 11/21 | 0.0 | 0/6 | 0.0 | 0/4 | 0.0 | 0/1 | 34.4 | 11/32 | |
Data are from January to June. Two cases of IMD-E (1 case) and IMD-X (1 case) are not included in the table. Total includes cases of serogroup W, B, Y, and C.
Abbreviations: CFR, case fatality rate; IMD, invasive meningococcal disease; NaN, not a number (dividing by zero is undefined).
a P values for the difference between variables and CFR among cases from all serogroups.
bOne case with missing information on gender.
cData available only since 2017.
dIMD-specific symptoms: petechiae and/or neck stiffness.