Table 2.

Clinical Information and Resistance Status of the Isolates

Family	ID	Recruitmenta	Disease Status	Clinical Form at Diagnosis, WHO	Resistanceb			Resistance Genotype
					Dapsone	Rifampin	Ofloxacin	folP1	rpoB	gyrA
A	PA-043	2009 and 2013	Relapse	MB	Resistantc	Resistantc	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)/ GAT441TAT (Asp-Tyr)d	WT
A	PA-073	2009	New case	PB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
A	PA-074	2009	New case	PB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
A	PA-220	2013	New case	PB	Resistant	Resistant	Unknown	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	PCR neg
A	PA-221	2013	Relapse	MB	Susceptible	Susceptible	Susceptible	WT	WT	WT
B	PA-084	2009 and 2013	Relapse	MB	Resistantc	Resistantc	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
B	PA-085	2009 and 2013	Relapse	PB	Resistant	Resistant	Unknown	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	PCR neg
C	PA-058	2009	New case	PB	Susceptible	Susceptible	Susceptible	WT	WT	WT
C	PA-103	2009	New case	PB	Resistant	Unknown	Unknown	CCC55CGC (Pro-Arg)	PCR neg	PCR neg
D	PA-118	2009	New case	PB	Susceptible	Susceptible	Susceptible	WT	WT	WT
D	PA-119	2009	New case	PB	Unknown	Resistant	Susceptible	PCR neg	TCG456ATG (Ser-Met)	WT
E	PA-192	2009 and 2013	Relapse	MB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
E	PA-199	2009	New case	MB	Unknown	Unknown	Unknown	PCR neg	PCR neg	PCR neg
…	PA-006	2009	Relapse	MB	Susceptible	Susceptible	Susceptible	WT	WT	WT
…	PA-012	2009 and 2013	Relapse	MB	Susceptiblec	Susceptiblec	Susceptible	PCR neg	PCR neg	WT
…	PA-016	2009	Relapse	MB	Resistant	Resistant	Susceptible	ACC53GCC (Thr-Ala)	TCG456TTG (Ser-Leu)	WT
…	PA-034	2013	Relapse	MB	Susceptible	Susceptiblec	Susceptible	WT	CTA470CAA (Leu-Gln)	WT
…	PA-040	2009	Relapse	MB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
…	PA-067	2009	Relapse	MB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
…	PA-070	2009	New case	PB	Unknown	Susceptible	Susceptible	PCR neg	WT	WT
…	PA-131	2009	Relapse	MB	Susceptible	Susceptible	Susceptible	WT	WT	WT
…	PA-146	2009	Relapse	MB	Resistant	Susceptible	Susceptible	CCC55CGC (Pro-Arg)	WT	WT
…	PA-155	2009	Relapse	MB	Resistantc	Susceptible	Susceptible	CCC55CTC (Pro-Leu)	WT	WT
…	PA-164	2009	New case	PB	Unknown	Unknown	Unknown	PCR neg	PCR neg	PCR neg
…	PA-167	2009	New case	MB	Unknown	Unknown	Susceptible	PCR neg	PCR neg	WT
…	PA-208	2013	Relapse	MB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
…	PA-213	2013	New case	PB	Unknown	Unknown	Unknown	PCR neg	PCR neg	PCR neg
…	PA-214	2013	Relapse	MB	Susceptible	Susceptible	Unknown	WT	WT	TTA97TTT (Leu-Phe)
…	PA-215	2013	New case	PB	Unknown	Unknown	Unknown	PCR neg	PCR neg	PCR neg
…	PA-232	2013	New case	PB	Unknown	Unknown	Unknown	PCR neg	PCR neg	PCR neg
…	PA-235	2013	New case	PB	Resistant	Resistant	Susceptible	CCC55CGC (Pro-Arg)	TCG456ATG (Ser-Met)	WT
…	PA-240	2013	Relapse	MB	Unknown	Unknown	Unknown	PCR neg	PCR neg	PCR neg
…	PA-243	2013	New case	PB	Susceptible	Unknown	Unknown	WT	PCR neg	TTA97TTT (Leu-Phe)
…	PA-245	2013	New case	PB	Susceptible	Unknown	Susceptible	WT	PCR neg	WT
…	PA-246	2013	New case	MB	Susceptible	Unknown	Susceptible	WT	PCR neg	WT
…	PA-248	2013	Relapse	MB	Unknown	Susceptible	Susceptible	CGG100TGG (Arg- Trp)	WT	WT
…	PA-254	2013	New case	PB	Susceptible	Susceptible	Susceptible	WT	WT	WT

Abbreviations: ID, identification number; MB, multibacillary; PB, paucibacillary; PCR neg, not amplified polymerase chain reaction; WHO,World Health Organization classification; WT, wild type.

^aFirst step in 2009 and second step in 2013.

^bResistance inferred from mutations in drug resistance–determining regions that have been proved to cause resistance.

^cResistance confirmed on mice test (in vivo).

^dVariant GAT441TAT (Asp-Tyr) has not been detected in any other members of the family.