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. 2019 Jul 24;70(10):2073–2081. doi: 10.1093/cid/ciz653

Table 1.

Solicited and Unsolicited Symptoms Within the 30-Day Postvaccination Period

Study Arm Doses, n Any Symptom, n (%) Grade 3, n (%) With Causal Relationship, n (%) Grade 3 With Causal Relationship, n (%)
All doses ChAd-RSV-LD 14 12 (86) 1 (7) 10 (71) 1 (7)
ChAd-RSV-HD 59 53 (90) 6 (10) 48 (81) 2 (3)
Placebo 38 28 (73) 3 (8) 21 (55) 1 (3)
Active 30 30 (100) 7 (23) 30 (100) 6 (20)
Dose 1 ChAd-RSV-LD 7 7 (100) 1 (14) 5 (71) 1 (14)
ChAd-RSV-HD 31 29 (94) 4 (13) 27 (87) 1 (3)
Placebo 19 14 (74) 3 (16) 11 (58) 1 (5)
Active 15 15 (100) 4 (27) 15 (100) 3 (20)
Dose 2 ChAd-RSV-LD 7 5 (71) 0 (-) 5 (71) 0 (-)
ChAd-RSV-HD 28 24 (86) 2 (7) 21 (75) 1 (4)
Placebo 19 14 (74) 0 (-) 10 (53) 0 (-)
Active 15 15 (100) 3 (20) 15 (100) 3 (20)

The placebo was a saline solution and the active dose was an active control.

Abbreviations: ChAd155, chimpanzee-adenovirus-155 vaccine; HD, high dose; LD, low dose; RSV, respiratory syncytial virus.