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. 2020 Jan 13;2020:2460158. doi: 10.1155/2020/2460158

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Copyright © 2020 Wenbin Lu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Conversion of Ly6C^high to Ly6C^low monocytes in AMI mice following transplantation with MSCs. (a) Ly6C^low monocyte levels in the circulation of AMI C57BL/6^CX3CR1-/- and AMI C57BL/6 AMI mice day 3. (b) Circulating Ly6C^low monocytes in AMI C57BL/6^CX3CR1-/- mice with or without MSC transplantation on day 1 and day 3. (c) Levels of Ly6C^low monocytes infiltrated in the AMI hearts of C57BL/6^CX3CR1-/- mice with or without MSC transplantation on day 1and day 3. (d) Levels of NR4A1 in AMI hearts of C57BL/6^CX3CR1-/- mice were then tested. ^∗p < 0.05 at day 3 vs. the first day. Abbreviations: FITC: fluorescein isothiocyanate; MSCs: mesenchymal stem cells; PE: phycoerythrin; NR4A1: nuclear receptor subfamily 4 group A member 1; CX3CR1: C-X3-C motif chemokine receptor 1.