Table 2.
Antienteropooling effects of C. abyssinica extract and solvent fractions.
| Treatment given | VSIC (ml) | % inhibition in volume | WSIC (g) | % inhibition in weight | |
|---|---|---|---|---|---|
| Negative control | 0.86 ± 0.03 | — | 0.91 ± 0.03 | — | |
|
| |||||
| Extract (mg/kg) | 100 | 0.74 ± 0.03e∗∗∗ | 14.48 | 0.80 ± 0.03e∗∗ | 11.56 |
| 200 | 0.62 ± 0.03e∗∗ | 28.18 | 0.73 ± 0.02e∗ | 19.44 | |
| 400 | 0.47 ± 0.02a∗∗ | 45.74 | 0.50 ± 0.02a∗ | 45.42 | |
|
| |||||
| Solvent fractions (mg/kg) | CF 100 | 0.68 ± 0.05e∗∗∗ | 10.23 | 0.78 ± 0.09e∗∗ | 25.50 |
| CF 200 | 0.47 ± 0.33a∗∗ | 25.09 | 0.65 ± 0.05 | 48.44 | |
| CF 400 | 0.39 ± 0.04a∗∗∗b∗ | 47.68 | 0.45 ± 0.121a∗ | 56.88 | |
| n-BF 100 | 0.67 ± 0.06e∗∗∗ | 20.65 | 0.69 ± 0.13 | 26.60 | |
| n-BF 200 | 0.43 ± 0.03a∗∗∗b∗ | 50.39 | 0.49 ± 0.03a∗ | 45.87 | |
| n-BF 400 | 0.35 ± 0.08a∗∗∗b∗∗ | 51.73 | 0.42 ± 0.09a∗∗ | 61.47 | |
| AF 100 | 0.55 ± 0.08a∗e∗ | 33.20 | 0.58 ± 0.12 | 39.45 | |
| AF 200 | 0.50 ± 0.12a∗∗ | 41.70 | 0.51 ± 0.10 | 44.40 | |
| AF 400 | 0.33 ± 0.10a∗∗∗b∗∗ | 43.24 | 0.49 ± 0.09a∗ | 63.86 | |
|
| |||||
| Positive control | 0.20 ± 0.07a∗∗∗b∗∗∗ | 65.25 | 0.30 ± 0.11a∗∗∗b∗∗ | 77.98 | |
Values are expressed as mean ± SEM (n=6); analysis was performed using one-way ANOVA followed by Tukey's post hoc test; acompared to negative control, bcompared to 100 mg/kg crude extract, ccompared to 200 mg/kg crude extract, dcompared to 400 mg/kg crude extract, ecompared to positive control. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. CF = chloroform fraction; n-BF = n-butanol fraction; AF = aqueous fraction; VSIC = volume of small intestinal content; WSIC = weight of small intestinal content.