Table 1.
Demographic, systemic disease status, and 8-hydroxy-2′-deoxyguanosine levels between patients with primary open-angle glaucoma and healthy controls.
| Variables | Controls (n = 45) | POAG (n = 50) | p value |
|---|---|---|---|
| Age in years, mean (SD) | 59.9 (8.3) | 62.3 (9.2) | 0.191a |
| Male/female, n | 30/15 | 28/22 | 0.287b |
| Systemic diseases, n (%) | |||
| Diabetes mellitus | 6 (13.3) | 8 (16.0) | 0.714b |
| Hypertension | 5 (11.1) | 7 (14.0) | 0.672b |
| Coronary artery disease | 2 (4.4) | 4 (8.0) | 0.477b |
| Hypercholesterolemia | 2 (4.4) | 3 (6.0) | 0.735b |
| Family history of glaucoma | 1 (2.2) | 9 (18.0) | 0.012b |
| Smokers | 5 (11.1) | 7 (14.0) | 0.672b |
| 8-OHdG levels, ng/mL | |||
| Mean (SD) | 16.95 (10.66) | 22.61 (12.05) | 0.018a |
| Median | 13.78 | 18.35 | 0.010c |
| Males | |||
| Mean (SD) | 17.02 (11.02) | 23.15 (12.24) | 0.049a |
| Median | 13.12 | 18.08 | 0.024c |
| Females | |||
| Mean (SD) | 16.80 (10.29) | 21.92 (12.06) | 0.188a |
| Median | 17.97 | 19.24 | 0.254c |
Note. aIndependent sample t-test (two-tailed); bChi2 test; cMann–Whitney U test. 8-OHdG, 8-hydroxy-2′-deoxyguanosine; POAG, primary open-angle glaucoma.