Table 3.
Plasma levels of 8-hydroxy-2′-deoxyguanosine and the risk of primary open-angle glaucoma.
| 8-OHdG cutoff ng/mL | Controls no. (%) | POAG no. (%) | Odds ratio (95% confidence interval) | p valuea |
|---|---|---|---|---|
| By quartiles†∗ | ||||
| <11.18 | 17 (33.3) | 6 (12.0) | Reference | – |
| 11.18–26.60 | 19 (26.6) | 30 (60.0) | 4.47 (1.49 – 13.35) | 0.005 |
| >26.60 | 9 (40.0) | 14 (28.0) | 4.40 (1.26 – 15.41) | 0.017 |
|
| ||||
| By ROC curve | ||||
| <14.80 | 24 (53.3) | 11 (22.0) | Reference | |
| ≥14.80 | 21 (46.6) | 39 (78.0) | 4.05 (1.66 – 9.86) | 0.002 |
Note. aPearson's Chi2 test; †first quartile (<25th percentile); interquartile (25th–75th percentile); third quartile (>75th percentile). ∗Overall Chi2 = 8.58, df = 2, p < 0.014. 8-OHdG, 8-hydroxy-2′-deoxyguanosine; POAG, primary open-angle glaucoma; ROC, receiver operator characteristic.