Fig. 7.

No signs of toxicity were observed in ATO-treated mice. Normal mice were administered intraperitoneal injections of normal saline, ATO (0.5 mg/kg/day) or ATO (1 mg/kg/day) for 20 days. a Heart, liver, and kidney samples were collected for HE staining. Scale bar = 50 μm. b The levels of ALT, AST, creatinine, and urea in the serum were measured using an automated biochemical analyzer. c Representative TUNEL staining sections of the spinal cord. Scale bar = 100 μm. n = 5 mice/group. Data are representative of three independent experiments. ALT, alanine aminotransferase; AST, aspartic aminotransferase