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. 2020 May 6;11:29. doi: 10.1186/s13229-020-00340-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Acute rapamycin treatment did not affect the deficit in synaptic inhibition. a Diagram of experimental paradigm for acute treatment of slices with 200 nM rapamycin (or vehicle) and recording of synaptic inhibition of pyramidal cells by Nkx2.1 interneurons from Nkx2.1^Cre/wt;Tsc1^f/wt mutant and Nkx2.1^Cre/wt control mice. b, c Representative traces (b) and summary graph (c) of input-output function of IPSCs evoked in CA1 pyramidal cells by optogenetic stimulation of Nkx2.1 interneurons in slices from Nkx2.1^Cre/wt;Tsc1^f/wt mutant (red) and Nkx2.1^Cre/wt control (black) mice that received vehicle (filled symbols) or rapamycin (open symbols). Acute rapamycin treatment did not affect the reduction of IPSC amplitude in mutant relative to control mice (n = 9 cells in 4 animals for vehicle-treated and 7 cells in 4 animals for rapamycin-treated Wt mice (Nkx2.1^Cre/wt;Tsc1^wt/wt); n = 6 cells in 4 animals for vehicle-treated and 4 cells in 3 animals for rapamycin-treated Tg mice (Nkx2.1^Cre/wt;Tsc1^f/wt); 3-way ANOVA, Bonferroni tests, **p < 0.01, n.s. not significant)