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. 2020 May 6;11:170. doi: 10.1186/s13287-020-01679-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Enhanced miR-153 expression attenuates the stemness properties of lung cancer cells. a miR-153 expression in SPC-A-1 cells after miR-153 overexpression was determined by qPCR. b Tumor sphere formation capacity of SPC-A-1 cells was analyzed after miR-153 overexpression. Scale bar, 100 μm. c Stem cell markers (MSI-1 and Snail) expression in control and miR-153-overexpressing cells was analyzed by quantitative PCR. d The MSI-1 and snail protein levels in indicated cells were determined by western blot. e Stem cell marker CD133 expression was determined by immunofluorescence. Scale bar, 50 μm. Data shown are mean ± s.d. of three independent experiments. *P < 0.05, ***P < 0.001 by two tailed Student’s t test