Table 2.

Peak velocity of early diastolic septal mitral annular motion (E′), peak velocity of diastolic septal mitral annular motion (A′), ratio of the peak velocity of early diastolic mitral annular motion to the peak velocity of diastolic mitral annular motion (E′/A′), mid systolic myocardial velocity gradient (MVGs), early diastolic myocardial velocity gradient (MVGe), and atrial systolic myocardial velocity gradient (MVGa) after eplerenone (EP) administration in dogs.

Variables	Group	Time after EP administration (weeks)
		0	1	2	4
E′ (cm/s)	EP 2.5	8.1 ± 0.4	8.6 ± 0.6	9.5 ± 0.5	8.5 ± 0.4
	EP 5	8.1 ± 0.3	9.0 ± 0.4	8.7 ± 0.5	8.0 ± 0.4
	EP 10	7.6 ± 0.6	8.4 ± 0.7	8.7 ± 0.8	8.1 ± 0.5
A′ (cm/s)	EP 2.5	5.7 ± 0.4	5.9 ± 0.3	6.3 ± 0.5	5.3 ± 0.3
	EP 5	5.1 ± 0.3	5.9 ± 0.4	5.5 ± 0.3	5.2 ± 0.4
	EP 10	5.0 ± 0.3	6.1 ± 0.4	5.7 ± 0.3	4.9 ± 0.2
E′/A′	EP 2.5	1.44 ± 0.09	1.46 ± 0.09	1.53 ± 0.11	1.59 ± 0.08
	EP 5	1.63 ± 0.10	1.55 ± 0.10	1.58 ± 0.12	1.57 ± 0.14
	EP 10	1.50 ± 0.08	1.38 ± 0.08	1.53 ± 0.11	1.66 ± 0.07
MVGs (s)	EP 2.5	2.61 ± 0.17	2.04 ± 0.19	1.94 ± 0.30	1.72 ± 0.18a
	EP 5	2.38 ± 0.34	1.79 ± 0.28	1.86 ± 0.29	1.56 ± 0.18
	EP 10	1.94 ± 0.13	1.71 ± 0.23	1.77 ± 0.27	1.60 ± 0.25
MVGe (s)	EP 2.5	−1.74 ± 0.34	−2.38 ± 0.61	−2.47 ± 0.58	−2.54 ± 0.58
	EP 5	−1.44 ± 0.19	−1.62 ± 1.00	−2.44 ± 0.56	−2.48 ± 0.43
	EP 10	−1.71 ± 0.26	−2.21 ± 0.26	−2.58 ± 0.20	−2.24 ± 0.38
MVGa (s)	EP 2.5	−1.19 ± 0.24	−0.36 ± 0.92	−0.64 ± 0.51	−1.01 ± 0.47
	EP 5	−0.58 ± 0.73	−1.45 ± 0.30	−0.69 ± 0.58	−0.60 ± 0.43
	EP 10	−0.93 ± 0.16	−1.01 ± 0.17	−1.24 ± 0.17	−1.34 ± 0.34

Each value represents the mean ± standard error (n=5). EP 2.5, 5, and 10: eplerenone 2.5, 5, and 10 mg/kg, respectively. ^aValue differs significantly from the baseline (time 0) value at P < 0.05.