Table 2.
Novel HERV-K (HML-2) integration loci
| Locus | Coordinate | Orientation | Type | Flanking region |
|---|---|---|---|---|
| Reference HERV-K (HML-2) integration loci | ||||
| solo-1p35.1 | Chr1: 33529117-33530085 | (+) | LTR5_Hs | – |
| solo-3p12.3 | Chr3: 75586870-75587898 | (+) | LTR5A | 1.3 kb upstream of CTD-2023G6.3 |
| solo-3q21.2 | Chr3: 125518094-125519118 | (−) | LTR5A | 1.3 kb downstream of LOC105374312 |
| solo-4p16.3 | Chr4: 4076017-4077040 | (+) | LTR5A | BC042823 (exon5/5) |
| solo-4p16.1a | Chr4: 9036143-9037177 | (−) | LTR5A | – |
| solo-4p16.1b | Chr4: 9568938-9569963 | (−) | LTR5A | AF073924 (intron 13/41) |
| solo-6p22.2 | Chr6: 25999459-26000425 | (+) | LTR5_Hs | U91328.19 (exon 2/2) |
| solo-7p14.3 | Chr7: 30758200-30759205 | (−) | LTR5B | INMT (intron 1/3) |
| solo-8p23.1a | Chr8: 12481601-12482613 | (+) | LTR5A | LOC729732 (intron 2/5) |
| solo-8p23.1b | Chr8: 6984509-6985529 | (−) | LTR5A | – |
| solo-8p23.1c | Chr8: 7957620-7958646 | (−) | LTR5A | FAM85B (exon 4/4) |
| solo-8p12 | Chr8: 29976041-29976903 | (−) | LTR5B | LEPROTL1 transcript variant 2 (intron3/3) |
| solo-10q24.1 | Chr10: 99176602-99177875 | (−) | LTR5_Hs | 0.6 kb upstream of LOC644215, with Alu int |
| solo-11q12.2 | Chr11: 60480658-60481952 | (−) | LTR5_Hs | MS4A8 (intron5/6), with Alu int |
| solo-11p15.4a | Chr11: 3566582-3567605 | (+) | LTR5A | LOC101927708 (intron1/2) |
| solo-11p15.4b | Chr11: 4481698-4482706 | (−) | LTR5B | – |
| solo-12q23.3 | Chr12: 108220231-108221198 | (−) | LTR5_Hs | KJ893228 (coding PRDM4) (intron 4/13) |
| solo-16q23.1 | Chr16: 75848903-75850194 | (−) | LTR5_Hs | with Alu int |
| solo-19q13.41 | Chr19: 53435868-53437508 | (−) | LTR5B | ZNF321P (intron1/1), with Alu int |
| solo-19p12 | Chr19: 23459830-23461346 | (−) | LTR5B | with LTR6A int |
| solo-20p11.21a | Chr20: 23736917-23737884 | (−) | LTR5_Hs | |
| solo-20p11.21b | Chr20: 23674997-23675964 | (−) | LTR5_Hs | |
| solo-Yq11.223 | ChrY: 26026513-26027237 | (−) | LTR5_Hs | – |
| solo-Yq11.23 | ChrY: 27935164-27935888 | (+) | LTR5_Hs | – |
| solo-Un212 | Un_gl000212: 79707-80671 | (+) | LTR5_Hs | – |
| solo-Un219 | Un_gl000219: 31165-32127 | (−) | LTR5_Hs | – |
| solo-Un222 | Un_gl000222: 107341-108304 | (−) | LTR5_Hs | – |
| solo-Un231 | Un_gl000231: 22479-23506 | (+) | LTR5A | – |
| solo-Un232a | Un_gl000232: 2327-3289 | (+) | LTR5_Hs | – |
| solo-Un232b | Un_gl000232: 8571-9521 | (−) | LTR5_Hs | – |
| Non-reference HERV-K (HML-2) integration loci | ||||
| N3q22.1 | Chr3: 130166557-130166563 | (+) | HERVK11-int, COL6A5 (intron 36/41) | |
| N6p21.32 | Chr6: 32643459-32643464 | (+) | LTR5_Hs | L1PA10 |
| N15q21.2 | Chr15: 51650823-51650829 | (+) | HERV17-int, GLDN (intron 1/9) | |
| N19q11 | Chr19: 28198583-28198588 | (+) | inserted into HERV17-int | |
| N21q22.11 | Chr21: 33824215-33824220 | (−) | MLT1C, EVA1c (intron 1/7) | |