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. 2020 May 6;17:146. doi: 10.1186/s12974-020-01811-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Microglia influence the phenotype of PdgfRα+ late embryonic OPCs in the tuberal hypothalamus. a Illustrative diagram depicting the GM and WM areas from which PdgfRα immunolabeled sample bins were set to capture percent area coverage calculations. b Representative PdgfRα immunostained regions from control and PLX5622 treated embryonic coronal brain slices from the GM area at E15.5 and E17.5. Arrows indicate examples of PdgfRα+ cells that appear amoeboid in the control but ramified in the PLX5622 treated. c Percent area coverage of PdgfRα+ cells from control and PLX5622 treated embryonic coronal brain slices at E15.5 and E17.5 from the GM area (ANOVA, P < 0.0001). d Representative PdgfRα immunostained regions from control and PLX5622 treated embryonic coronal brain slices from the WM area at E15.5 and E17.5. e Percent area coverage of PdgfRα+ cells from control and PLX5622 treated embryonic coronal brain slices at E15.5 and E17.5 from the WM area (ANOVA, P < 0.0001). Samples: n = 5, 5 embryo brains for control and PLX5622 respectively for both E15.5 and E17.5 time points. Graphs: Bar graph with mean ± SD. Statistics: ANOVA with Tukey post hoc; **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001