Table 1.
Characteristics of the BP patients and the healthy controls in the qPCR-based array and qPCR validation studies.
| qPCR-based array study | qPCR validation study | |||
|---|---|---|---|---|
| BP patients (n = 20) | HCs (n = 20) | BP patients (n = 45) | HCs (n = 60) | |
| Age (years) median (IQR) | 72.5 (60.75-81.75) | 38.5 (30-54) | 73 (61-82) | 48.5 (42-55) |
| Sex (female/male) | 12/8 | 16/4 | 20/25 | 26/34 |
| Disease duration (months) median (IQR) | 2 (0.62-3.5) | NA | 2 (1-3.5) | NA |
| Previous history, n (%) | 7 (35) | 0 | 17 (37.78) | 0 |
| Hypertension, n | 2 | 0 | 14 | 0 |
| Cerebrovascular disease, n | 7 | 0 | 9 | 0 |
| Mucosal involvement, n (%) | 2 (10) | 0 | 10 (22.22) | 0 |
| Positive IIF, n (%) | 16 (80) | NA | 36 (80) | NA |
| Anti-BP180 (U/mL) | ||||
| >9, n (%) | 16 (80) | NA | 38 (84.44) | NA |
| Anti-BP230 (U/mL) | ||||
| >9, n (%) | NA | NA | 25 (55.56) | NA |
| CCL17 (pg/mL) median (IQR) | NA | NA | 1368 (410-2088) | 248.5 (143.4-376.7) |
| miR-1291 (2-ΔCt), median (IQR) | 1.01 (0.33-2.03) | 0.25 (0.07-0.51) | 0.31 (0.13-0.89) | 0.06 (0.05-0.12) |
BP: bullous pemphigoid; qPCR: quantitative polymerase chain reaction; HCs: healthy controls; IQR: interquartile ranges; NA: not available.