Table 2.

Correlated miRNA - gene expression pairs in ESCC^a

No.	miRNA	miRNA fold changeb	No. correlated genes	Correlated gene	Gene fold changec	Rho	P-value
1	has-miR-155	1.73	3	PSMB9	2.50	0.57	<10E-12
				BTN3A3 /// BTN3A2	1.70	0.55	6.80E-10
				UBE2L6	1.90	0.54	2.20E-09
2	hsa-miR-133a	0.19	2	SLC2A1	2.40	−0.52	4.50E-09
				SLC6A8	1.90	−0.52	7.10E-09
3	hsa-miR-135a*	0.89	1	BC37295_3	0.83	0.53	2.80E-09
4	hsa-miR-145	0.29	1	SMC4	1.20	−0.54	1.50E-09
5	hsa-miR-149	0.4	6	IFI30	2.40	−0.52	4.80E-09
				PSME2	1.70	−0.52	6.30E-09
				GZMA	1.50	− 0.52	5.40E-09
				PSMB8	1.80	− 0.54	6.00E-10
				TRA@ /// TRD@	1.10	− 0.54	1.30E-09
				PSMB9	2.50	−0.56	3.70E-12
6	hsa-miR-150	0.49	5	CCR7	1.10	0.57	0
				IGHM	0.94	0.54	1.10E-09
				SELL	1.30	0.52	4.70E-09
				CCL19	0.81	0.52	6.70E-09
				MS4A1	1.10	0.52	5.80E-09
7	hsa-miR-200b	1.11	7	GPR116	1.10	−0.52	7.40E-09
				DMD	0.58	−0.53	4.90E-09
				IL33	0.61	−0.53	2.60E-09
				RFTN1	1.20	−0.53	4.30E-09
				PPARGC1A	0.71	−0.53	4.70E-09
				GPM6A	0.68	−0.54	1.50E-09
				GEM	0.80	−0.56	1.40E-10
8	hsa-miR-203	0.31	146	DSG3	0.45	0.63	<10E-12
				CST6	0.35	0.62	<10E-12
				IL1RN	0.16	0.62	<10E-12
				MAP3K9	0.50	0.62	<10E-12
				GLTP	0.28	0.62	<10E-12
				AIM1L /// FLJ38020	0.29	0.62	<10E-12
				PPL	0.17	0.61	<10E-12
				SERPINB13	0.19	0.61	<10E-12
				FBXO34	0.57	0.61	<10E-12
				EVPL	0.29	0.60	<10E-12
				SPRR1B	0.43	0.60	<10E-12
				SERPINB13	0.22	0.60	<10E-12
				SPRR1A	0.27	0.60	<10E-12
				RAPGEFL1	0.54	0.60	<10E-12
				ZNF750	0.29	0.60	<10E-12
				(for full set of genes correlated with miR-203, see Supplementary TableS3)
9	hsa-miR-205	0.89	5	F12	1.10	0.57	<10E-12
				STX6	1.10	0.54	1.30E-09
				HSPA4	0.85	0.52	6.90E-09
				MGC24039	0.97	−0.52	5.60E-09
				PFAAP5	0.90	−0.53	3.50E-09
10	hsa-miR-214	1.17	3	CHAF1A	1.40	−0.52	4.70E-09
				EZH2	2.10	−0.54	1.60E-09
				TMPO	1.50	−0.54	8.50E-10
11	hsa-miR-224	1.56	1	F12	1.10	0.53	2.00E-09
12	hsa-miR-320	0.51	2	ACOX2	0.50	0.51	6.60E-09
				EZH2	2.10	−0.54	4.40E-10
13	hsa-miR-375	0.02	2	IL1RN	0.16	0.59	9.90E-10
				PSG3	0.62	0.58	1.40E-09
14	hsa-miR-574–3p	0.45	5	ADD1	0.72	0.53	2.30E-09
				GAS7	0.52	0.52	7.00E-09
				EZH2	2.10	−0.52	7.80E-09
				TMPO	1.50	−0.52	5.60E-09
				C13orf34	1.90	−0.52	4.80E-09
15	hsa-miR-650	0.98	15	LOC91316	1.50	0.64	<10E-12
				POU2AF1	1.70	0.60	<10E-12
				CTA-246H3.1	1.80	0.58	<10E-12
				MGC29506	1.30	0.58	<10E-12
				CD79A	1.00	0.55	2.50E-10
				IGHA1 /// IGHG1 /// IGHG3 /// IGHM	1.20	0.55	5.90E-10
				IL8	1.60	0.54	2.10E-09
				IVD	1.60	0.54	1.20E-09
				CXCL13	2.80	0.53	3.20E-09
				IGL@	2.30	0.53	3.70E-09
				IGKC /// NTN2L /// GJB6	2.40	0.53	2.60E-09
				IGL@ /// IGLV4–3 /// IGLV3–25 /// IGLV2–14 /// IGLJ3	2.30	0.53	3.10E-09
				IGL@ /// IGLV4–3 /// IGLV3–25 /// IGLV2–14	2.10	0.53	5.10E-09
				HLA-C	2.00	0.52	6.30E-09
				IGL@ /// IGLV3–25 /// IGLV2–14 /// IGLJ3	2.10	0.52	5.90E-09
16	hsa-miR-99b	0.79	1	SMC4	1.20	−0.52	4.40E-09

^aP-value threshold for multiple comparison adjustment = P < 8.40E-09 (0.05/5,947,959)

^bmedian miRNA fold change

^cmean gene expression fold change