Table 1.

Parameters of the PC mathematical model. According to this model, only two parameters r and a_P are personalized and depend on the immunology system of the patients.

	Definition	Value	Units
k i	Rate of DC maturation following vaccine uptake	0.06	h−1
n ν	Number of vaccine cells required to induce maturation of one DC	1	—
V p	Natural influx of mature DCs	0	cells
k m	Rate of DC migration from skin to lymph node	0.027	h−1
α l	Fraction of antigen-presenting DCs entering the lymph node	0.03	–
k CR	Rate of exhaustion of mature DCs	0.027	h−1
μ D	Death rate of exhausted DCs	0.014	h−1
a R	Rate of inhibitory cell recruitment by exhausted DCs	3 · 10−3	h−1
μ R	Death rate of inhibitory cells	0.03	h−1
a C	Rate of effector cell recruitment by mature DCs	0.38	h−1
μ C	Effector cell death rate	0.007	h−1
k R	Rate of effector cell inactivation by inhibitory cells	6 · 10−7	cell−1 · h−1
r	Tumour growth rate	Personalized; range from 10−5 to 10−3	h−1
a p	Maximal PCa cell killing efficacy	Personalized; range from 0 to 2 · 10−6	cell−1 · h−1
h P	Effector cell efficacy damping coefficient	108	Cells