. 2020 May 6;9:15. doi: 10.1186/s40035-020-00192-4

Table 3.

Logistic regression analysis of multiple CSF biomarkers

Ctrl Group
Asymptomatic carriers	t-α-syn o-α-syn TNF-α	0.997 (0.994–0.999) 1.029 (0.999–1.060) 1.418 (0.998–2.014)	AUC: 0.843 (0.724–0.961) Sens: 87.5%, Spec: 66.7%	0.000
PD (i.e. sPD & symptomatic LRRK2 mutation carriers)	t-α-syn o-α-syn pS129-α-syn IL-16	0.996 (0.994–0.999) 1.031 (1.005–1.056) 1.035 (1.010–1.059) 0.785 (0.60–1.022)	AUC: 0.896 (0.823–0.969) Sens: 87.0% Spec: 78.6%	0.000

Ctrl Group

Predictors

OR (95% CI)

Accuracy of model

Asymptomatic carriers

t-α-syn

o-α-syn

TNF-α

0.997 (0.994–0.999)

1.029 (0.999–1.060)

1.418 (0.998–2.014)

AUC: 0.843 (0.724–0.961)

Sens: 87.5%,

Spec: 66.7%

0.000

PD (i.e. sPD & symptomatic LRRK2 mutation carriers)

t-α-syn

o-α-syn

pS129-α-syn

IL-16

0.996 (0.994–0.999)

1.031 (1.005–1.056)

1.035 (1.010–1.059)

0.785 (0.60–1.022)

AUC: 0.896 (0.823–0.969)

Sens: 87.0%

Spec: 78.6%

0.000

AUC area under the curve, HC Healthy controls, NPV negative predictive value, OR odds ratio, o-α-syn oligomeric α-synuclein, PD sporadic and symptomatic LRRK2 mutation patients, PPV positive predictive value; pSer129-α-synuclein, phosphorylated α-synuclein protein at serine 129, Sens sensitivity, Spec specificity, TNF-α tumor necrosis factor-alpha, t-α-syn total α-synuclein