Table 2.
Clotting factor activity and levels in patient cohorts and adult controls
| SI | MI | CO | ||||||
|---|---|---|---|---|---|---|---|---|
| Activity/level | Median | IQR | Median | IQR | p* | Median | IQR | p* |
| Fibrinogen (mg/dl) | 198 | 80-242 | 239 | 195-253 | 0.20 | 296 | 204-324 | 0.034 |
| FII | 67 | 53-90 | 82 | 76-114 | 0.028 | 122 | 112-144 | < 0.001 |
| Ca (mmol/l) | 2.23 | 2.13-2.36 | 2.30 | 2.25-2.40 | 0.38 | 2.30 | 2.30-2.40 | 0.36 |
| FV | 76 | 47-85 | 92 | 82-99 | 0.028 | 123 | 100-142 | 0.002 |
| FVII | 71 | 63-97 | 89 | 75-107 | 0.16 | 114 | 100-152 | 0.009 |
| FVIII | 235 | 91-320 | 197 | 164-238 | 0.72 | 108 | 89-133 | 0.17 |
| FIX | 84 | 67-103 | 80 | 73-107 | 0.72 | 110 | 90-114 | 0.043 |
| FX | 70 | 61-85 | 79 | 65-115 | 0.33 | 122 | 96-140 | 0.001 |
| FXI | 112 | 80-122 | 93 | 77-119 | 0.72 | 106 | 97-119 | 0.97 |
| FXII | 107 | 66-132 | 98 | 67-117 | 0.65 | 99 | 90-104 | 0.90 |
| FXIII | 67 | 62-87 | 90 | 77-102 | 0.021 | 102 | 79-115 | 0.006 |
The clotting factor profiles of severely injured children (SI, n = 8) were compared with those of children with minor injury (MI, n = 8) and an adult control group (CO, n = 10). Coagulation factor activity is given as a percentage, except for fibrinogen and calcium (Ca). All variables represent median values together with interquartile range (IQR, 25th to 75th percentile)
*Mann-Whitney U test versus SI