Table 3.

Multivariable analyses between possible predictors and silent brain infarct/white matter hyperintensity volume using HOMA-IR instead of TyG index

	Silent brain infarct†		White matter hyperintensity‡
	Adjusted OR (95% CI)	P-value	β (95% CI)	P-value
Age	1.09 [1.07–1.11]	< 0.001	0.054 (0.049 to 0.059)	< 0.001
Sex, male	0.87 [0.63–1.22]	0.426	0.023 (− 0.063 to 0.109)	0.601
Body mass index	0.99 [0.94–1.05]	0.816	− 0.012 (− 0.027 to 0.003)	0.124
Use of antihypertensives	1.55 [1.07–2.25]	0.021	0.275 (0.165 to 0.384)	< 0.001
Use of antiplatelet agents	0.93 [0.51–1.68]	0.801	− 0.060 (− 0.227 to 0.108)	0.484
hs-CRP*	1.03 [0.93–1.15]	0.553	–	–
WBC counts	–	–	0.029 (0.003 to 0.055)	0.031
HOMA-IR*	1.32 [1.02–1.71]	0.036	0.075 (0.013 to 0.137)	0.018

HOMA-IR: Homeostatic Model Assessment for Insulin Resistance; hs-CRP: high-sensitivity C-reactive protein; WBC: white blood cell

^*These variables were transformed into a log scale

^†This analysis used a multivariable logistic regression analysis adjusted with P < 0.05 in univariate analysis (age, use of antihypertensives, use of antiplatelet agents, hs-CRP, and HOMA-IR) and sex and BMI

^‡This analysis used a multivariable linear regression analysis adjusted with P < 0.05 in univariate analysis (age, use of antihypertensives, use of antiplatelet agents, White blood cell counts, and HOMA-IR) and sex and BMI