Table 3.
Validated viral elimination when processing thrombin: Omrix process
| Step | Log kill or removal | |||||||
|---|---|---|---|---|---|---|---|---|
| Virus: | HIV‐1 | BVDV | Sindbis | PRV | EMCV | CPV | MMV | |
| Model for: | HIV | HCV | HCV | HBV | HAV | Parvovirus B19 | Parvovirus B19 | |
| Enveloped virus?: | Yes | Yes | Yes | Yes | No | No | No | |
| Cryo removal | ND | ND | ND | ND | ND | ND | ND | |
| Anion‐exchange chromatography | ND | ND | ND | ND | ND | ND | ND | |
| S/D treatment | >5.8* | >4.7† | >5.3‡ | >4.3† | ND | 0 | ND | |
| Cation‐exchange chromatography | ND | ND | ND | ND | ND | ND | ND | |
| Nanofiltration | >4.4 | ND | >5.3 | >5.5 | 7.0 | 5.9 | 5.8 | |
| Sum: | >10.2 | >4.7 | >10.6 | >9.8 | 7.0 | 5.9 | 5.8 | |
*
No infectivity after 5 minutes. Treatment is for 6 hours for thrombin.
†
No infectivity after 10 minutes, the first time point taken.
‡
No infectivity after 15 minutes, the first time point taken.
EMCV = encephalomyocarditis virus; MMV = mouse minute virus; ND = not done.