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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: J Am Chem Soc. 2020 Feb 20;142(9):4390–4399. doi: 10.1021/jacs.9b13173

Figure 1.

Figure 1.

(a) Cu-catalyzed oxidation-induced formal N–N reductive elimination for the synthesis of pyrazoles from electron-poor enamines and nitriles. (b) Ni-mediated N–N bond reductive elimination. (c) Formal [2+2+1] multicomponent synthesis of pyrazoles via oxidation-induced N–N coupling, and a proposed catalytic cycle for pyrazoles compared to the previously reported [2+2+1] synthesis of pyrroles.