Table 2.

List of compounds that have been tested as anti-tau therapeutic agents.

Name	Mechanism	References
Epothilone	Microtubule stabilizer	B. Zhang et al. J Neurosci, 32,3601–3611. Barten DM et al. J Neurosci, 32,7137–7145.
Davunetide	Microtubule stabilizer	Matsuoka Y et al. J Pharmacol Exp Ther, 325,146–153. Matsuoka Y et al. J Mol Neurosci, 31, 165–170.
Tideglusib	GSK3β inhibitor	Serenó L et al. Neurobiol Dis. 35(3):359–367.
Lithium	GSK3β inhibitor	Erin E et al. Nat Rev Neurol. 14(7): 399–415.
Zileuton	5 lipoxygenase inhibitor	Lauretti, E et al. Journal of Alzheimer’s disease 64(s1), S481–S489.
Sodium Selenite	Phosphatase modifier	van Eersel J et al. Proc Natl Acad Sci USA. 107(31):13888–13893.
Memantine	Phosphatase modifier NMDA antagonist	Erin E et al. Nat Rev Neurol. 14(7): 399–415.
Salsalate	NSAD Acetylation inhibitor	Min SW et al. Neurosci. 38(15):3680–3688.
Methylene Blue/LMT	Anti-tau aggregant	Congdon EE et al. Autophagy. 2012;8:609–622. Hochgrafe K et al. Acta Neuropathol Commun. 2015;3:25 Al-Hilaly et al. J Mol Biol. 2018 Oct 19;430(21):4119–4131
LMTX	Anti-tau aggregant	Melis et al. Cell Mol Life Sci. 2015 Jun;72(11):2199–222. Baddeley TC et al. J Pharmacol Exp Ther. 2015;352(1):110–8.
Curcumin	Anti-tau aggregant	Tsuyoshi H et al. CNS Neurosci Ther. 2010; 16(5): 285–297.
Rapamycin	Autophagy inducer (mTOR inhibitor)	Smita M et al. PLoS One. 2011;6(9):e25416. doi: 10.1371/journal.pone.0025416. Ozcelik S et al. PLoS One. 2013 May 7;8(5):e62459.
PU-DZ8	HSp90 inhibitor	Luo W et al. Proc Natl Acad Sci U S A. 2007;104(22):9511–6.
ASO	Tau expression modulator	DeVos SL et al. Sci Transl Med. 9(374). pii: eaag0481.
miR132/212	Tau expression modulator	Luikart, BW et al. PLOS ONE 6:e19077. Smith PY et al. Hum Mol Genet. 24(23):6721–635.
Anti-tau antibodies	Tau immunotherapy	Asuni AA, J Neurosci. 27(34):9115–29. Ando K et al. J Alzheimer’s Dis. 40 Suppl 1:S135–45. Selenica MB et al. Journal of Neuroinflammation. 11: 152 Castillo-Carranza DL et al. J. Neurosci 34, 4260–4272. Colin M et al. Acta Neuropathol 139, 3–25. Courade JP et al. Acta Neuropathol 136:729–745 Ando K et al. Am J Pathol. 178(2):803–16. Albert M et al. Brain. 142(6):1736–1750. Nobuhara CK et al. 187(6):1399–1412.