Table 3.

PCT inactivates gram‐positive and gram‐negative bacteria and spirochetes in plasma at high initial titers *

Bacteria	Pre‐PCT titer (n = 4)	Post‐PCT titer (n = 4)	Log‐reduction†
Gram‐positive
S. epidermidis	106.6±0.02 CFU/mL	<10−0.7±0 CFU/mL	>7.3 ± 0.02
Gram‐negative
K. pneumoniae	106.7±0.1 CFU/mL	<10−0.7±0 CFU/mL	>7.4 ± 0.1
Y. enterocolitica	106.6±0.01 CFU/mL	<10−0.7±0 CFU/mL	>7.3 ± 0.1
Spirochetes
T. pallidum	105.4±0.6 ID50/mL	<10−0.5±0 ID50/mL	>5.9 ± 0.6
B. burgdorferi	≥109.9±2.3 ID50/mL	<10−0.7±0 ID50/mL	>10.6 ± 2.3

^* Results are reported as mean ± SD. n = number of replicates done for each bacterium; ID₅₀/mL = infectious dose necessary for infection of 50 percent of inoculated cells or animal hosts;

^† Log‐reduction was calculated as the logarithm of the ratio of the pre‐PCT titer to the post‐PCT titer.