Table 4.

PCT inactivates protozoa in plasma at high initial titers *

Protozoa	Pre‐PCT titer (n = 4)	Post‐PCT titer (n = 4)	Log‐reduction†
P. falciparum	105.9±0 iRBCs/mL	≤10−1.0±0.3 iRBCs/mL	≥6.9 ± 0.3
T. cruzi ‡	106.3±0.6 TCID50/mL	<101.3±0 TCID50/mL	>5.0 ± 0.6
B. microti	104.9±0.4 ID50/mL	<100.5±0.02 ID50/mL	>5.3 ± 0.4

^* Results are reported as mean ± SD. n = number of replicates done for each protozoa; iRBCs/mL = infected red blood cells per milliliter; TCID₅₀/mL = infectious dose necessary for infection of 50 percent of inoculated cells; ID₅₀/mL = infectious dose necessary for infection of 50 percent of inoculated mice.

^† Log‐reduction was calculated as the logarithm of the ratio of the pre‐PCT titer to the post‐PCT titer.

^‡ Inactivation was done in 250 mL of whole‐blood derived plasma instead of the 600 mL apheresis plasma as specified under Materials and Methods.