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. 2020 Mar 31;217(5):e20191499. doi: 10.1084/jem.20191499

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© 2020 Kang et al.

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Figure S4. — Transcriptome profiling by RNA-Seq. (A–C) BMP2(−) condition. (A) A bar graph shows total number of DEGs with more than twofold changes (FDR < 1e-20) at 0-, 1-, and 2-wk time points in conventional osteogenic media without recombinant BMP2. (B) Clusters from degPatterns analysis of RNA-Seq data. The number of member genes in each cluster is also shown. (C) Cell growth inhibition by SMAD3 gain-of-function mutation. Heatmap of gene sets in eIF2 pathway displays significant down-regulation of ribosomal protein components (RPS [ribosomal protein S] and RPL (ribosomal protein L]) in affected cells. (D and E) BMP2(+) condition. (D) A bar graph shows total number of DEGs with more than twofold changes (FDR < 1e-20) at 0-, 1-, and 2-wk time points in conventional osteogenic media supplemented with recombinant BMP2. (E) 9 clusters from degPatterns analysis of RNA-Seq data. The number of member genes in each cluster is also shown. Aff, affected; Unaff, unaffected.