Table 1. Nomenclature of IL-6 family cytokines and their functions.
| Approved symbol (ligand) | Approved name | Gene symbol (alias) | Cellular expression | Function | Approved symbol (receptor) | Approved name | Gene symbol (alias) | Cellular expression |
|---|---|---|---|---|---|---|---|---|
| IL6 | IL-6 | IL-6, BSF2, HGF, HSF | Macrophage, DC, lymphocyte, epithelial cell, osteoclast, hepatocyte | Acute responses, angiogenesis, osteoclastogenesis, differentiation of Th17 subset and B cell, glucose metabolism | IL6R | IL-6 receptor | CD126 | Macrophage, monocyte, DC, hepatocyte, adipocyte |
| IL6ST | IL-6 signal transducer | GP130, CD130, sGP130 | Ubiquitous expression | |||||
| IL11 | IL=11 | IL-11, AGIF | Stromal cell line, fibroblast, chondrocytes, various cancers | Hematopoiesis, adipogenesis, neuronal differentiation, bone metabolism, cell proliferation, invasiveness | IL11RA | IL-11 receptor subunit α | Various cancers | |
| OSM | Oncostatin M | MGC20461 | Monocyte, macrophage, neutrophil, T cell | Hematopoiesis, bone turnover, lipid metabolism, liver regeneration | OSMR | Oncostatin M receptor | OSMRB, OSMRβ | Nonhematopoietic cell; hepatocyte, epithelial cell, endothelial cell, stromal cell, fibroblast cell |
| LIF | Leukemia inhibitory factor | CDF, DIA, HILDA | T cell, activated monocyte, fibroblast, endothelial cell | Bone remodeling, neural regeneration, | LIFR | LIF receptor subunit alpha | CD118 | skeletal muscle cell, cardiomyocyte |
| CTF1 | Cardiotrophin 1 | CT-1, CT1 | Cardiac myocyte | Apoptosis | ||||
| CNTF | Ciliary neurotrophic factor | HCNTF | Osteoblast, osteocyte, osteoclast, chondrocyte | Bone metabolism, glucose metabolism | CNTFR | Ciliary neurotrophic factor receptor | Skeletal muscle cell | |
| CLCF1 | Cardiotrophin-like cytokine factor 1 | NNT1, BSF3, CLC, NR6, CISS2, BSF-3, NNT-1 | Activated Jurkat human T cell lymphoma cell | Development of nervous system | ||||
| IL27 | IL-27 | IL-27, p28, IL27p28, IL-27A, IL27A, MGC71873 | Antigen-presenting cell | Differentiation of T cell subsets | IL27RA | IL-27 receptor subunit α | WSX-1, CCR, CRL1, WSX1, zcytor1, IL-27R | Macrophage, DC, T cell, B cell |
| EBI3 | Epstein-Barr virus–induced 3 | IL27B, IL35B | B cell | |||||
| IL12A | IL-12A | CLMF, IL-12A, p35, NFSK | Macrophage, DC, neutrophil | Differentiation of Th1, Th2 subset | IL12RB | IL-12 receptor subunit β | CD212 | T cell, NK cell |
| IL23A | IL-23 subunit α | SGRF, IL23P19, IL-23, IL-23A, p19 | IL23R | IL-23 receptor | IL-23R |
DC, dendritic cell; NK, natural killer.