Table 2. Age and season adjusted incidence ratio for first acute myocardial infarction (n = 606 individuals) and first stroke (n = 744 individuals) in periods after Streptococcus pneumoniae, respiratory viruses (combined) and influenza infections compared with baseline time, Denmark, 1 January 2010–31 December 2016.

Days after sample collection^a	Streptococcus pneumoniae			Respiratory viruses^b (combined)			Influenza
Days after sample collection^a	Events^c (n)	IR (CI 95%)	p value	Events^c (n)	IR (CI 95%)	p value	Events^c (n)	IR (CI 95%)	p value
Myocardial infarction
1–3	6	20.1 (8.9–45.8)	< 0.001	8	15.2 (7.5–31.1)	< 0.001	8	17.5 (8.5–36.2)	< 0.001
4–7	4	11.0 (4.1–29.8)	< 0.001	3	4.5 (1.4–14.0)	0.010	3	5.1 (1.6–16.3)	0.005
8–14	3	4.9 (1.6–15.6)	0.006	5	4.4 (1.8–10.8)	0.001	3	3.1 (1.0–9.7)	0.056
15–28	0	ND	ND	4	1.9 (0.7–5.1)	0.205	3	1.7 (0.5–5.3)	0.374
Baseline	Ref	1 (ref)	NA	Ref	1 (ref)	NA	Ref	1 (ref)	NA
Stroke
1–3	12	25.5 (14.2–45.8)	< 0.001	5	8.3 (3.4–20.2)	< 0.001	5	10.3 (4.2–25.4)	< 0.001
4–7	2	3.5 (0.9–14.1)	0.079	6	7.8 (3.4–17.5)	< 0.001	4	6.5 (2.4–17.7)	< 0.001
8–14	6	6.3 (2.8–14.4)	< 0.001	8	6.2 (3.0–12.6)	< 0.001	6	5.9 (2.6–13.4)	< 0.001
15–28	16	9.2 (5.5–15.4)	< 0.001	5	2.0 (0.8–4.9)	0.119	2	1.0 (0.3–4.2)	0.956
Baseline	Ref	1 (ref)	NA	Ref	1 (ref)	NA	Ref	1 (ref)	NA

CI: confidence interval; IR: incidence ratio; NA: not applicable; ND: could not be estimated (not determined); ref: reference.

^a The sample collection time approximates the time of symptom onset of the respiratory infection.

^b Human metapneumovirus, influenza virus, parainfluenza virus, respiratory syncytial virus and rhinovirus.

^c Events of first acute myocardial infarction or stroke.