Table 3. Age and season adjusted incidence ratio for first acute myocardial infarction (n = 555) and first stroke (n = 656) after excluding patients who died within 30 days of Streptococcus pneumoniae and respiratory viruses infections (combined) compared with baseline time, Denmark, 1 January 2010–31 December 2016.
| Days after sample collectiona | Streptococcus pneumoniae | Respiratory virusesb (combined) | ||
|---|---|---|---|---|
| IR (CI 95%) | p value | IR (CI 95%) | p value | |
| Myocardial infarction | ||||
| 1–3 | 18.2 (7.4–44.6) | < 0.001 | 14.8 (6.9–31.6) | < 0.001 |
| 4–7 | 11.4 (4.2–30.9) | < 0.001 | 4.9 (1.6–15.4) | 0.006 |
| 8–14 | 3.4 (0.8–13.6) | 0.090 | 3.9 (1.4–10.4) | 0.008 |
| 15–28 | ND | ND | 2.0 (0.8–5.5) | 0.157 |
| Baseline | 1 (ref) | NA | 1 (ref) | NA |
| Stroke | ||||
| 1–3 | 21.9 (10.7–44.6) | < 0.001 | 7.9 (2.9–21.2) | < 0.001 |
| 4–7 | 2.2 (0.3–15.9) | 0.425 | 7.6 (3.1–18.5) | < 0.001 |
| 8–14 | 7.8 (3.5–17.7) | < 0.001 | 6.2 (2.9–13.3) | < 0.001 |
| 15–28 | 9.6 (5.5–16.6) | < 0.001 | 1.4 (0.4–4.4) | 0.564 |
| Baseline | 1 (ref) | NA | 1 (ref) | NA |
CI: confidence interval; IR: incidence ratio; NA: not applicable; ND: could not be estimated; ref: reference.
a The sample collection time approximates the time of symptom onset due to infection with either Streptococcus pneumoniae or respiratory viruses.
b Human metapneumovirus, influenza virus, parainfluenza virus, respiratory syncytial virus and rhinovirus.