Table 2.

| HALs identified extracellularly

LncRNA	Extracellular space identified	Cell to Cell Transfer	Functional Impact	Mechanism	Ref
aHIF (HIF1A-AS2)	Serum (aHIF level in serum correlates with its expression in matched ectopic endometria)	Endometriotic cyst stromal cells (ECSCs)-derived exosomes to human umbilical vein endothelial cells (HUVECs)	Elicits proangiogenic behavior in HUVECs, thus facilitating endometriosis angiogenesis.	Activates VEGF-A, VEGF-D, and b-FGF in HUVECs	[133]
CCAT2	Exosomes secreted from cultured glioma cells	U87-MG glioma cells to HUVECs	Promotes HUVEC angiogenesis and inhibits apoptosis induced by hypoxia	Promotes VEGF-A, TGF-β and Bcl2 expression. Inhibits BAX and caspase 3 expression	[134]
HISLA (LINC01146)	Extracellular vesicles secreted by tumor associated fibroblasts (TAMs)	TAMs to breast cancer cells	Enhances aerobic glycolysis and apoptotic resistance of cancer cells	Stabilizes HIF-1α	[135]
PVT1	Exosomes secreted from cultured colon cancer cells. Cancer cells with more aggressive phenotypes have more extracellular PVT1	Not determined	Promotes cell proliferation and inhibits apoptosis.		[136]
linc-ROR	Exosomes secreted from cultured hepatocellular carcinoma cells	HCC cancer cells to cancer cells	Promotes cell survival of recipient cells	Through a miR-145–HIF-1α signaling module to increase HIF-1α expression	[87]
UCA1	Exosomes secreted from cultured bladder cancer cells & serum	Bladder cancer 5637 cells with high expression of UCA1 to bladder cancer UMUC2 cells with low expression of UCA1	Promotes cell proliferation, migration and invasion of recipient cells Promotes xenograft growth	Through regulating the expression of genes involved in EMT (E-cad, MMP9, vimentin)	[137]