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. 2020 May 6;19:83. doi: 10.1186/s12943-020-01196-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CircBFAR promotes tumor growth and metastasis of PDAC cells in vivo. a Representative images of subcutaneous xenograft tumors. b, c The tumor volume and weight dramatically decreased in sh-circBFAR#2 treated mice compared with those treated with the control shRNA. d, e Representative HE and IHC staining images of subcutaneous tumors revealed the relative protein levels of Ki-67 in different groups. The images were photographed at 200X (upper panel) or 400X (lower panel) magnification. Scale bar: black =100 μm; red =50 μm. f, g Representative IVIS images and analysis of luminescence intensity in lung in tail-vein injection model (n = 6 for each group). h Representative images of lung metastatic tumors. i HE staining of lung metastatic tumors. The images were photographed at 100X (upper panel) or 200X (lower panel) magnification. Scale bar: black =200 μm; red =100 μm. j The number of lung metastatic tumors decreased significantly in sh-circBFAR#2 treated mice. Statistical significance was assessed using two-tailed t-tests for two group comparison, and one-way ANOVA followed by Dunnett’s tests for multiple comparison. The error bars represent the standard deviations of three independent experiments. **P < 0.01