Table 4.
Multivariable analysis of transplants outcomes
| Variable | aGvHD II-IV | aGvHD III-IV | cGvHD | Ext. cGvHD | Relapse | NRM | LFS | OS | GRFS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | |
| Donor type | ||||||||||||||||||
| MSD | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| MUD |
1.39 (0.9–2.15) |
0.14 |
1.22 (0.56–2.64) |
0.61 |
0.96 (0.64–1.45) |
0.84 |
0.98 (0.57–1.7) |
0.95 |
0.79 (0.54–1.16) |
0.22 |
1.38 (0.74–2.61) |
0.32 |
0.93 (0.68–1.29) |
0.67 |
0.91 (0.63–1.3) |
0.59 |
1.01 (0.76–1.33) |
0.97 |
| Haplo |
1.60 (1.08–2.37) |
0.02 |
1.76 (0.92–3.37) |
0.09 |
1.21 (0.84–1.75) |
0.3 |
0.87 (0.53–1.42) |
0.57 |
0.67 (0.48–0.93) |
0.02 |
2.60 (1.5–4.49) |
< 0.001 |
1.07 (0.82–1.4) |
0.6 |
1.17 (0.86–1.6) |
0.31 |
1.03 (0.81–1.3) |
0.8 |
| Patient’s age per 10 years1 |
1.05 (0.96–1.17) |
0.29 |
1.00 (0.85–1.18) |
0.97 |
1.03 (0.93–1.14) |
0.57 |
0.95 (0.83–1.09) |
0.48 |
0.97 (0.88–1.06) |
0.49 |
1.35 (1.19–1.54) |
< 0.001 |
1.09 (1.02–1.18) |
0.02 |
1.21 (1.11–1.32) |
< 0.001 |
1.04 (0.97–1.11) |
0.26 |
| Karnofsky performance status | ||||||||||||||||||
| Poor (< 90) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| Good (≥ 90) |
0.92 (0.68–1.24) |
0.57 |
0.76 (0.47–1.23) |
0.27 |
0.79 (0.59–1.07) |
0.13 |
0.84 (0.55–1.3) |
0.44 |
0.88 (0.66–1.19) |
0.42 |
0.74 (0.53–1.04) |
0.08 |
0.8 (0.65–0.99) |
0.04 |
0.83 (0.66–1.06) |
0.13 |
0.8 (0.66–0.97) |
0.03 |
| Patient´s CMV serostatus | ||||||||||||||||||
| Negative | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| Positive |
0.97 (0.72–1.31) |
0.86 |
1.21 (0.71–2.05) |
0.49 |
0.86 (0.65–1.14) |
0.28 |
0.62 (0.42–0.92) |
0.02 |
1.24 (0.92–1.68) |
0.16 |
1.35 (0.91–1.99) |
0.13 |
1.27 (1–1.6) |
0.04 |
1.24 (0.96–1.6) |
0.1 |
1.02 (0.83–1.24) |
0.87 |
| Cytogenetic risk category | ||||||||||||||||||
| Poor | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| Standard or intermediate |
0.9 (0.66–1.22) |
0.48 |
1.01 (0.59–1.7) |
0.98 |
1.08 (0.79–1.48) |
0.63 |
0.78 (0.5–1.21) |
0.26 |
0.58 (0.43–0.78) |
<0.001 |
1.01 (0.69–1.48) |
0.96 |
0.73 (0.59–0.92) |
0.007 |
0.7 (0.54–0.9) |
0.005 |
0.78 (0.63–0.96) |
0.02 |
| Not available |
0.77 (0.53–1.12) |
0.17 |
0.73 (0.39–1.36) |
0.32 |
0.92 (0.64–1.34) |
0.66 |
0.65 (0.39–1.1) |
0.11 |
0.69 (0.49–0.97) |
0.03 |
1 (0.65–1.54) |
1 |
0.79 (0.61–1.02) |
0.07 |
0.81 (0.61–1.07) |
0.14 |
0.81 (0.64–1.03) |
0.08 |
| Type of AML | ||||||||||||||||||
| De novo | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| Secondary |
0.86 (0.61–1.22) |
0.4 |
1.03 (0.59–1.79) |
0.92 |
1 (0.72–1.37) |
0.98 |
0.83 (0.49–1.4) |
0.48 |
1.20 (0.87–1.64) |
0.27 |
1.08 (0.76–1.55) |
0.67 |
1.18 (0.93–1.49) |
0.17 |
1.20 (0.93–1.54) |
0.16 |
1.11 (0.89–1.38) |
0.36 |
| Time from diagnosis to SCT1,2 |
0.93 (0.83–1.05) |
0.24 |
0.85 (0.68–1.06) |
0.16 |
0.86 (0.75–0.98) |
0.03 |
0.9 (0.75–1.09) |
0.29 |
0.93 (0.82–1.06) |
0.29 |
1.02 (0.89–1.16) |
0.79 |
0.98 (0.89–1.07) |
0.6 |
1 (0.9–1.1) |
0.93 |
0.96 (0.89–1.04) |
0.37 |
| Conditioning intensity | ||||||||||||||||||
| RIC | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| MAC |
1.01 (0.76–1.35) |
0.93 |
1.12 (0.7–1.8) |
0.64 |
1.04 (0.77–1.41) |
0.81 |
0.75 (0.5–1.13) |
0.17 |
0.58 (0.43–0.77) |
<0.001 |
0.95 (0.68–1.32) |
0.74 |
0.71 (0.58–0.88) |
0.001 |
0.76 (0.60–0.96) |
0.02 |
0.79 (0.66–0.95) |
0.01 |
| Stem cell source | ||||||||||||||||||
| Bone marrow | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| Peripheral blood |
1.93 (1.39–2.67) |
< 0.001 |
1.86 (1.1–3.15) |
0.02 |
1.72 (1.24–2.39) |
0.001 |
1.86 (1.15–3.01) |
0.01 |
0.74 (0.55–0.99) |
0.04 |
1.07 (0.76–1.51) |
0.69 |
0.9 (0.73–1.11) |
0.31 |
0.96 (0.75–1.22) |
0.73 |
1.13 (0.93–1.38) |
0.2 |
| Donor-recipient gender | ||||||||||||||||||
| Other combinations | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| Female donor to male recipient |
0.87 (0.63–1.18) |
0.37 |
1.05 (0.63–1.75) |
0.85 |
1.19 (0.9–1.58) |
0.23 |
1.71 (1.14–2.57) |
0.009 |
0.87 (0.64–1.2) |
0.4 |
1.11 (0.79–1.56) |
0.54 |
0.99 (0.79–1.24) |
0.94 |
1.00 (0.79–1.29) |
0.97 |
1.08 (0.88–1.32) |
0.48 |
| Center effect | 0.04 | 0.27 | 0.01 | 0.28 | 0.22 | 0.06 | 0.25 | 0.13 | 0.28 | |||||||||
1Continuous variable
2By 2 months increase