Schematic of the photonic crystal sensor, analogous to that of an SPR chip, and detects signals as molecules on the crystal surface interact with the analytes. Changes in the environment adjacent to the crystal surface changes the intensity of the light with total internal reflection. Reprinted with permission from Petrova, I.; Konopsky, V.; Nabiev, I.; Sukhanova, A. Label-Free Flow Multiplex Biosensing via Photonic Crystal Surface Mode Detection. Sci. Rep. 2019, Vol. 9, 8745 (ref 140). Copyright 2019 Springer Nature.