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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Antiviral Res. 2017 Oct 31;148:20–31. doi: 10.1016/j.antiviral.2017.10.021

Figure 1. Morbidity and mortality of immunocompetent and immunosuppressed mice inoculated with influenza B viruses.

Figure 1.

Female 6- to 8-week-old immunocompetent and immunosuppressed (DEX+CP-treated) BALB/c mice (n = 5/group) were anesthetized with isoflurane and inoculated intranasally with influenza B viruses at a range of doses (102–105 TCID50/mouse in 30 μL). The graphs show the weight loss (A, C, E, and G) and survival (B, D, F, and H) of immunocompetent mice inoculated with PH/13 (A, B) or BR/08 (C, D) viruses and of immunosuppressed mice inoculated with PH/13 (E, F) or BR/08 (G, H) viruses. Control uninfected animals (black line) received sterile PBS (A-D) or DEX+CP (E-H). The horizontal dotted line in panels A, C, E, and G indicates the endpoint for mortality (25% loss of initial weight). The probabilities of survival were determined by Kaplan-Meier and log-rank tests. Abbreviations: DEX+CP, dexamethasone and cyclophosphamide; PH/13, B/Phuket/3073/2013; BR/08, B/Brisbane/60/2008.