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. 2020 Apr 29;8:291. doi: 10.3389/fcell.2020.00291

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Copyright © 2020 Zheng, Li, Zhang and Sui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The main components of the m⁶A system in plants include writers, erasers, and readers. The writers consist of MTA, FIP37, MTB, HAKAI, and VIRILIZER. The demethylases are mainly ALKBH2, ALKBH9B, and ALKBH10B. The m⁶A binding proteins are mainly ECT family proteins and CPSF30, both of which contain a YTH domain. The writers and erasers are responsible for adding or removing m⁶A site on RNA. The readers interact with m⁶A-modified RNA and regulate RNA splicing, RNA stability, and 3′UTR processing. This figure was created using smart Servier Medical Art (https://smart.servier.com/).