(A) Heatmap shows correlation of phospho-STING (Ser_366) protein levels with CGAS and other immune related proteins in the MD Anderson PROSPECT cohort, including treatment naïve adenocarcinoma (n=120, Spearman’s rho > 0.3, p<0.001).
(B) Expression of the STING downstream chemokine CXCL10 is correlated with the other STING related genes CCL5 and CGAS (p<0.001), with expression of selected targetable immune genes: CD274 (PD-L1), LAG3, CTLA4, IDO1, HAVCR2 and ICOS (Spearman’s rho > 0.5, p<0.001) and with CD8 mRNA levels, indicative of immune infiltration in PROSPECT LUAD cohort (n=120). (C-D) Individual dot-plots showing correlation of CXCL10
(C) and CCL5
(D) gene expression with selected targetable genes CD274 and CTLA4, and CD8 in PROSPECT LUAD cohort (n=120). (E) Correlation of CXCL10 with CCL5 and CGAS gene expression, with selected targetable immune genes and other immune markers from the list of Chen et al. in the treatment-refractory and relapsed BATTLE-2 cohort (n=95, Spearman’s rho > 0.3, p<0.001). (F-G) Individual dot-plots showing correlation of CXCL10
(F) and CCL5
(G) gene expression with selected targetable genes CD274 and CTLA4, and CD8 in BATTLE-2 cohort.