Table 1:

Baseline characteristics of patients with versus without acute coronary syndrome after TAVR

Variable	Without ACS	With ACS	P value
N	136,104	6,741
Age	81.7±8.1	80.7±8.8	<0.0001
Male	52.7	55.3	<0.001
White	92.5	91.2	<0.001
Black	3.9	5.3
Other	3.5	3.4
Hypertension	93.8	95.1	<0.0001
Diabetes mellitus	40.9	51.5	<0.0001
Heart failure	79.3	83.9	<0.001
Deficiency anemia	40.8	50.3	<0.001
Alcohol abuse	2.0	1.7	0.10
Connective tissue disease	6.7	7.7	<0.001
Chronic lung disease	38.5	43.8	<0.001
Coagulopathy	22.4	24.1	0.001
Depression	15.2	12.7	0.002
Drug abuse	0.7	1.0	0.02
Hypothyroidism	25.7	26.1	0.44
Liver disease	3.8	3.8	0.90
Lymphoma	1.8	1.9	0.70
Electrolyte abnormality	43.6	51.9	<0.001
Metastasis	1.2	0.9	0.04
Obesity	24.3	27.0	<0.0001
Paralysis	4.0	4.9	0.0004
Peripheral arterial disease	35.6	46.4	<0.0001
Psychosis	2.7	3.5	0.0002
Pulmonary hypertension	18.2	25.5	<0.0001
Tumor without metastasis	5.1	5.4	0.32
Underweight	1.7	1.4	0.10
Weight loss	8.7	9.5	0.02
Prior bleeding	34.1	41.8	<0.0001
Cerebral hemorrhage	0.7	0.8	0.31
Prior stroke	16.6	22.6	<0.0001
End stage renal disease on dialysis	3.5	7.0	<0.0001
Chronic kidney disease	28.7	34.7	<0.0001
Prior coronary artery disease	79.8	90.8	<0.0001
Prior smoking	26.3	38.7	<0.0001
Prior revascularization (within 3 years prior to TAVR)	35.3	55.2	<0.0001
Prior ACS (within 1 year prior to TAVR)	7.9	21.6	<0.0001
PCI (within 6 months prior to TAVR)	7.4	14.9	<0.0001
Prior ICD	4.2	5.1	0.0004
Preexisting atrial fibrillation	43.6	40.7	<0.001
Prior pacemaker	13.9	13.7	0.70
Apical TAVR	7.2	12.8	<0.001
Valve-in-TAVR valve	0.4	1.1	<0.001
Aortic aneurysm	1.9	1.0	<0.0001
TAVR in Bicuspid AS	1.2	1.0	0.18

ACS=Acute coronary syndrome, ICD=intracardiac defibrillator, TAVR=transcatheter aortic valve replacement; PCI= percutaneous coronary intervention