Table 2.
Potential targets of miRNAs in steroidogenic pathways.
| Species/steroidogenic tissues/cells | miRNA | Potential targets of steroidogenic enzymes or protein factors | Reference |
|---|---|---|---|
| Adrenal steroidogenic pathways | |||
| Human tissue samples and human H295R adrenocortical cells Human H295R adrenocortical cells Human H295 adrenocortical cells Mouse Y1 adrenocortical tumor cells Human adrenal tissue, and human H295R adrenocortical cells |
miRNA-24 miRNA-10b miRNA-98 miRNA-132 DICER1 miRNA-125a-5p miRNA-125b-5p miRNA-24 miRNA-320a-3p miRNA-10b miRNA-579, miRNA-561 |
CYP11B1, CYP11B2 CYP11B1, CYP11B2 CYP19A1 StAR, Mecp2 CYP11A1, CYP11B1, CYP21A, CYP17A1, CYP11B2 CYP11B2 CYP11B2 CYP11B1, CYP11B2 CYP11A1, CYP17A1 CYP11B1, CYP11B2 HSD11B1 |
Robertson et al. 2013, Nusrin et al. 2014, Yu et al. 2015, Hu et al. 2017, Robertson et al. 2013, 2017, Clayton et al. 2018 |
| Ovarian steroidogenic pathways | |||
| Porcine ovarian cumulus granulosa cells Mouse ovarian granulosa cells Primary mouse ovarian granulosa cells, and human granulosa-like tumor cell line, KGN Rat ovaries Primary human ovarian granulosa cells Mouse ovarian granulosa cells Human ovarian granulosa-like tumor cell line Primary mouse ovarian granulosa cells Porcine ovarian granulosa cells Human ovarian cumulus granulosa cells and human granulosa-like tumor cell line, KGN Mouse ovarian granulosa cells Human ovarian granulosa like tumor cell line, KGN Mouse ovarian granulosa cells, and mouse granulosa-like tumor cell line, KK-1 Human ovarian granulosa-like tumor cell line, KGN Human ovarian cumulus granulosa cells Porcine ovarian granulosa cells Rat ovary Buffalo ovaries and buffalo ovarian granulosa cells. Human ovarian cumulus granulosa cells and human granulosa-like tumor cell line, KGN Human ovarian cumulus granulosa cells Ovine ovarian granulosa cells |
miRNA-378 miRNA-383 miRNA-133b miRNA-5131-3p miRNA-513a-3p miRNA-320, miRNA-383 miRNA-592 miRNA-132 miRNA-126* miRNA-509-3p miRNA-764-3p let-7b miRNA-27a-3p miRNA-375 miRNA-320a miRNA-1275 miRNA-122 miRNA-210 miRNA-323-3p miRNA-320a miRNA-150 |
CYP19A1 RBMS1 Foxl2 LHCGR LHCGR E2F1, SF-1 LHCGR Nurr1 FSHR MAP3K8 SF-1 StAR Creb1 SP1 RUNX2 LRH-1 LRBP, SREBP-1a/SREBP-2, LHCGR HRas, EFNA3 IGF-1 RUNX2 StAR |
Xu et al. 2011, Pan et al. 2015, Yin et al. 2012, Dai et al. 2013, Kitahara et al. 2013, Troppmann et al. 2014, Yin et al. 2014, Song et al. 2015, Wu et al. 2015, Du et al. 2016b, Huang et al. 2016, Wang et al. 2016a, Men et al. 2017, Wang et al. 2017, Tu et al. 2019, Zhang et al. 2017a, Liu et al. 2018, Menon et al. 2018, Shukla et al. 2018, Wang et al. 2019, Zhang et al. 2019a, Zhou et al. 2019 |
| Testicular steroidogenic pathways | |||
| Mouse testicular Leydig tumor MLTC-1 cells Mouse testicular Leydig tumor MLTC-1 cells Mouse testicular Leydig cells Mouse testicular Leydig tumor MLTC-1 cells Mouse testicular Leydig tumor MA-10 cells Primary rat testicular Leydig cells and Mouse testicular Leydig tumor TM3 cells |
miRNA-125a, miRNA-455 miRNA-200c miRNA-150 let-7b MiRNA-146a-5p miRNA-6321 |
SR-B1 Vimentin STAR Star Mta-3 Map3k1 |
Hu et al. 2012, Hu et al. 2017, Geng et al. 2017, Men et al. 2017, Gao et al. 2018, Ha et al. 2018 |
Creb1, cAMP-responsive element-binding protein1; E2F1, E2F transcription factor 1, FSHR, follicle-stimulating hormone receptor; Foxl2, forkhead Box L2; IGF-1, insulin-like growth factor-1; LHCGR, luteinizing hormone/chorionic gonadotropin receptor; LRBP, luteinizing hormone receptor (LHR) mRNA-binding protein; LRH-1, liver receptor homolog-1; MAP3K1, mitogen-activated protein kinase, kinase, kinase1; MAP3K8, mitogen-activated protein kinase kinase kinase 8; Mecp2, methyl CpG-binding protein; Mta-3, metastasis-associated 3; Nur77, orphan nuclear receptor Nur77 (also known as NR4A1, NGF1B, TR3TIS1, NAK or N10); Nurr1, Nurr1 transcription factor, also called nuclear receptor subfamily 4 group A member 2 (Nr4a2); RBMS1, RNA-binding motif single-stranded interacting protein 1; RUNX2, Runt-related transcription factor also known as core binding factor subunit alpha-1 (CBP-alpha-1); SR-B1, scavenger receptor class B, type 1; SREBP-1a, sterol regulatory element-binding protein1a; SREBP-2, sterol regulatory element-binding protein2; STA R/StAR/Star, steroidogenic acute regulatory protein; SF-1, steroidogenic factor 1.