Table 1.
Updated assignment of RyR1 residues into domains based on Des Georges et al 28
| Domain name | Abbreviation | Residues | |
|---|---|---|---|
| 1 | N‐terminal domains A and B | AB domain | 1–392 |
| 2 | N‐terminal solenoid | Nsol | 393–627 |
| 3 | SP1a/ryanodine receptor domain 1 | SPRY1 | 628–849 |
| 4 | RYR repeats 1 and 2 | Repeat 1–2 | 850–1,054 |
| 5 | SP1a/ryanodine receptor domain 2 | SPRY2 | 1,055–1,241 |
| 6 | SP1a/ryanodine receptor domain 3 | SPRY3 | 1,242–1,656 |
| 7 | Junctional solenoid | Jsol | 1,657–2,144 |
| 8 | Bridging solenoid | Bsol | 2,145–3,613 |
| 9 | RYR repeats 3 and 4 | Repeat 3–4 | 2,735–2,938 |
| 10 | Shell‐core linker peptide, CaM and JSol binding sites | SCLP | 3,614–3,666 |
| 11 | Core solenoid | Csol | 3,667–4,174 |
| 12 | EF‐hand pair | EF1&2 | 4,060–4,134 |
| 13 | Thumb and forefingers domain | TaF | 4,175–4,253 |
| 14 | Auxiliary transmembrane helices | TMx | 4,322–4,370 |
| 15 | Sarcoplasmic extensions | SExt | 4,371–4,540 |
| 16 | Pseudo‐voltage‐sensor domain | pVSD | 4,541–4,819 |
| 17 | Helical‐bundle domain between S2 and S3 | S2S3 | 4,666–4,786 |
| 18 | Channel pore domain | Pore | 4,820–4,956 |
| 19 | Cytoplasmic extension of S6 | S6c | 4,938–4,956 |
| 20 | C‐terminal domain | CTD | 4,957–5,037 |