Table 1.
miRNA | Species | Proposed effect on growth | Molecular target(s) | Reference |
---|---|---|---|---|
miR-8/ miR200 | Drosophila | Promotes growth by increasing PI3K activation | USH/FOG2 | (Hyun et al. 2009) |
miR-200 | Zebrafish | Suppresses growth by targeting GH-IGF-I signaling | GH, GHR, IGF2a | (Jing et al. 2015) |
miR-9a | Drosophila | Suppresses growth by targeting insulin signaling | sNPFR1/NPY2R | (Suh et al. 2015) |
miR-1/ miR-133 | Mouse | Suppresses cardiac hypertrophy | RohA, Cdc42, Nelf-A/WHSC2 | (Care et al. 2007) |
let-7 | Mouse | Suppresses growth by regulating glucose metabolism and insulin sensitivity | Myc, Kras, Igf2bp1, Hmga2 | (Zhu et al. 2010) (Frost & Olson 2011) |
miR-29 | Mouse | Suppresses organs growth by targeting a genetic program | Igf1, Mest, Igfbp1 | (Kamran et al. 2015) |